tailieunhanh - Báo cáo y học: "Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of the Macaca mulatta transcriptome and the sequence divergence between Macaca and human. | Method Open Access Analysis of the Macaca mulatto transcriptome and the sequence divergence between Macaca and human Charles L Magness P Campion Fellin Matthew J Thomas Marcus J Korth Michael B Agy Sean C Prolh Matthew Fitzgibbon Christina A Scherer Douglas G Miner Michael G Katzen and Shawn P ladonato Addresses Illumigen Biosciences Inc. Suite 450 2203 Airport Way South Seattle WA 98134 USA. ỶDepartment of Microbiology University of Washington Seattle WA 98195-8070 USA. Washington National Primate Research Center University of Washington Seattle WA 981958070 USA. Correspondence Shawn P ladonato. E-mail siadonato@ Published 30 June 2005 Genome Biology 2005 6 R60 doi 186 gb-2005-6-7-r60 The electronic version of this article is the complete one and can be found online at http 2005 6 7 R60 Received 18 January 2005 Revised 4 April 2005 Accepted 23 May 2005 2005 Magness et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract We report the initial sequencing and comparative analysis of the Macaca mulatta transcriptome. Cloned sequences from 11 tissues nine animals and three species M. mulatta M. fascicularis and M. nemestrina were sampled resulting in the generation of 48 642 sequence reads. These data represent an initial sampling of the putative rhesus orthologs for 6 216 human genes. Mean nucleotide diversity within M. mulatta and sequence divergence among M. fascicularis M. nemestrina and M. mulatta are also reported. Background The sequencing of genes and genomes has become a hallmark of modern molecular biology. The resulting wealth of nucleotide sequence information has fostered advances in gene discovery the development of genome-based technologies to study gene expression and