tailieunhanh - Báo cáo y học: "Patterns and rates of intron divergence between humans and chimpanzees"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Patterns and rates of intron divergence between humans and chimpanzees. | Open Access Research Patterns and rates of intron divergence between humans and chimpanzees Elodie Gazave Tomàs Marqués-Bonet Olga Fernando ỷ Brian Charlesworth and Arcadi Navarro Addresses Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut Universitat Pompeu Fabra Carrer Dr Aiguader 88 08003 Barcelona Catalonia Spain. fInstituto de Tecnologia Química e Biológica ITQB Universidade Nova de Lisboa Av. da República EAN 2781-901 Oeiras Lisboa Portugal. institute of Evolutionary Biology University of Edinburgh West Mains Road Edinburgh Scotland EH7 3JT UK. Institucio Catalana de Recerca i Estudis Avancats ICREA Unitat de Biologia Evolutiva Departament de Ciències Experimentals i de la Salut Universitat Pompeu Fabra Carrer Dr Aiguader 88 08003 Barcelona Catalonia Spain. Correspondence Arcadi Navarro. Email Published 19 February 2007 Genome Biology 2007 8 R21 doi gb-2007-8-2-r2l The electronic version of this article is the complete one and can be found online at http 2007 8 2 R2l Received 2 August 2006 Revised 8 December 2006 Accepted l9 February 2007 2007 Gazave et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Introns which constitute the largest fraction of eukaryotic genes and which had been considered to be neutral sequences are increasingly acknowledged as having important functions. Several studies have investigated levels of evolutionary constraint along introns and across classes of introns of different length and location within genes. However thus far these studies have yielded contradictory results. Results We present the first analysis of human-chimpanzee intron divergence in which differences in the number of .