tailieunhanh - Báo cáo y học: "Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence. | Open Access Research Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence Ian J Donaldson and Berthold Gottgens Address Department of Haematology Cambridge Institute for Medical Research University of Cambridge Cambridge CB2 2XY UK. Correspondence BertholdGottgens. Email bg200@ Published 29 June 2006 Genome Biology 2006 7 R52 doi 186 gb-2006-7-6-r52 The electronic version of this article is the complete one and can be found online at http 2006 7 6 R52 Received 4 April 2006 Revised 1 June 2006 Accepted 9 June 2006 2006 Donaldson and Gottgens licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Despite the recent completion of the chimpanzee genome project few functionally significant sequence differences between humans and chimpanzees have thus far been identified. Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change suggesting that a significant proportion of functional human-chimpanzee sequence differences may affect regulatory elements. Results To explore this hypothesis we performed genome-wide identification of conserved candidate transcription-factor binding sites that have evolved since the divergence of humans and chimpanzees. Analysis of candidate transcription-factor binding sites conserved between mouse and chimpanzee yet absent in human indicated that loss of candidate transcription-factor binding sites in the human lineage was not random but instead correlated with the biologic functions of associated genes. Conclusion Our data support the notion that changes in transcriptional regulation have contributed to the recent evolution of humans. Moreover genes associated with

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