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Báo cáo y học: "Evolutionary rate and gene expression across different brain regions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Evolutionary rate and gene expression across different brain regions. | Open Access Research Evolutionary rate and gene expression across different brain regions Tamir Tuller Martin Kupieđ and Eytan Ruppin Addresses School of Computer Sciences Tel Aviv University Ramat Aviv 69978 Israel. Department of Molecular Microbiology and Biotechnology Tel Aviv University Ramat Aviv 69978 Israel. School of Medicine Tel Aviv University Ramat Aviv 69978 Israel. Correspondence TamirTuller. Email tamirtul@post.tau.ac.il. Eytan Ruppin. Email ruppin@post.tau.ac.il Published 23 September 2008 Received 20 August 2008 Genome Biology 2008 9 R142 doi 10.1186 gb-2008-9-9-r142 Accepted 23 September 2008 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 9 R142 2008 Tuller et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The evolutionary rate of a protein is a basic measure of evolution at the molecular level. Previous studies have shown that genes expressed in the brain have significantly lower evolutionary rates than those expressed in somatic tissues. Results We study the evolutionary rates of genes expressed in 21 different human brain regions. We find that genes highly expressed in the more recent cortical regions of the brain have lower evolutionary rates than genes highly expressed in subcortical regions. This may partially result from the observation that genes that are highly expressed in cortical regions tend to be highly expressed in subcortical regions and thus their evolution faces a richer set of functional constraints. The frequency of mammal-specific and primate-specific genes is higher in the highly expressed gene sets of subcortical brain regions than in those of cortical brain regions. The basic inverse .