tailieunhanh - Báo cáo y học: "Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Eggshell and egg yolk proteins in fish: hepatic proteins for the next generation: oogenetic, population, and evolutionary implications of endocrine disruption. | Comparative Hepatology BioMed Central Review Open Access Eggshell and egg yolk proteins in fish hepatic proteins for the next generation oogenetic population and evolutionary implications of endocrine disruption Augustine Arukwe 1 and Anders Goksoyr2 3 Address 1Great Lakes Institute for Environmental Research University of Windsor Ontario 401 Sunset Avenue Windsor N9B 3P4 Canada 2Biosense Laboratories AS Thormohlensgt. 55 N-5008 Bergen Norway and 3Department of Molecular Biology University of Bergen N-5020 Bergen Norway Email Augustine Arukwe - arukwe@ Anders Goksoyr - anders@ Corresponding author Published 6 March 2003 Received 14 November 2002 Accepted 6 March 2003 Comparative Hepatology 2003 2 4 This article is available from http content 2 l 4 2003 Arukwe and Goksoyr licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract The oocyte is the starting point for a new generation. Most of the machinery for DNA and protein synthesis needed for the developing embryo is made autonomously by the fertilized oocyte. However in fish and in many other oviparous vertebrates the major constituents of the egg . yolk and eggshell proteins are synthesized in the liver and transported to the oocyte for uptake. Vitellogenesis the process of yolk protein vitellogenin synthesis transport and uptake into the oocyte and zonagenesis the synthesis of eggshell zona radiata proteins their transport and deposition by the maturing oocyte are important aspects of oogenesis. The many molecular events involved in these processes require tight coordinated regulation that is under strict endocrine control with the female sex steroid hormone estradiol-l7p in a central role. The ability of many synthetic chemical compounds to mimic this estrogen can lead to .