tailieunhanh - Báo cáo y học: "Evolutionary history and functional implications of protein domains and their combinations in eukaryotes"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài:Evolutionary history and functional implications of protein domains and their combinations in eukaryotes. | Open Access Research Evolutionary history and functional implications of protein domains and their combinations in eukaryotes Masumi Itoh Jose C Nacher Kei-ichi Kuma Susumu Goto and Minoru Kanehisa Address Bioinformatics Center Institute for Chemical Research Kyoto University Gokasho Uji Kyoto 611-0011 Japan. Correspondence Minoru Kanehisa. Email kanehisa@ Published 25 June 2007 Genome Biology 2007 8 R121 doi gb-2007-8-6-rl 21 The electronic version of this article is the complete one and can be found online at http 2007 8 6 R121 Received 9 February 2007 Revised 10 May 2007 Accepted 25 June 2007 2007 Itoh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In higher multicellular eukaryotes complex protein domain combinations contribute to various cellular functions such as regulation of intercellular or intracellular signaling and interactions. To elucidate the characteristics and evolutionary mechanisms that underlie such domain combinations it is essential to examine the different types of domains and their combinations among different groups of eukaryotes. Results We observed a large number of group-specific domain combinations in animals especially in vertebrates. Examples include animal-specific combinations in tyrosine phosphorylation systems and vertebrate-specific combinations in complement and coagulation cascades. These systems apparently underwent extensive evolution in the ancestors of these groups. In extant animals especially in vertebrates animal-specific domains have greater connectivity than do other domains on average and contribute to the varying number of combinations in each animal subgroup. In other groups the connectivities of older