tailieunhanh - Báo cáo y học: "Evolutionary conservation of regulated longevity assurance mechanisms"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Evolutionary conservation of regulated longevity assurance mechanisms. | Open Access Research Evolutionary conservation of regulated longevity assurance mechanisms Joshua J McElwee Eugene Schuster Eric Blanc Matthew D Piper James H Thomas Dhaval S Patel Colin Selman Dominic J Withers Janet M Thornton Linda Partridge and David Gems Addresses Department of Biology University College London London WC1E 6BT UK. Department of Genome Sciences University of Washington Seattle Washington 98195-5065 USA. European Bioinformatics Institute Hinxton CB10 1SD UK. Department of Medicine University College London London WC1E 6BT UK. These authors contributed equally to this work. Correspondence David Gems. Email Published 5 July 2007 Genome Biology 2007 8 R132 doi gb-2007-8-7-r132 The electronic version of this article is the complete one and can be found online at http 2007 8 7 R132 Received 5 December 2006 Revised 16 May 2007 Accepted 5 July 2007 2007 McElwee et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background To what extent are the determinants of aging in animal species universal Insulin insulin-like growth factor IGF -1 signaling IIS is an evolutionarily conserved public regulator of longevity yet it remains unclear whether the genes and biochemical processes through which IIS acts on aging are public or private that is lineage specific . To address this we have applied a novel multi-level cross-species comparative analysis to compare gene expression changes accompanying increased longevity in mutant nematodes fruitflies and mice with reduced IIS. Results Surprisingly there is little evolutionary conservation at the level of individual orthologous genes or paralogous genes under IIS regulation. However a number of gene categories are .

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