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Báo cáo y học: "Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers. | Open Access Research Analysis of gene expression in a developmental context emphasizes distinct biological leitmotifs in human cancers Kamila Naxerova Carol J Bult Anne Peaston Karen Fancher Barbara B Knowles Simon Kasif and Isaac S Kohane Addresses Children s Hospital Informatics Program Harvard-MIT Division of Health Sciences and Technology Longwood Avenue Boston MA 02115 USA. The Jackson Laboratory Main Street Bar Harbor ME 04609 USA. Department of Biomedical Engineering Boston University Cummington Street Boston MA 02215 USA. Correspondence Isaac S Kohane. Email isaac_kohane@harvard.edu Published 8 July 2008 Genome Biology 2008 9 R108 doi 10.1186 gb-2008-9-7-r108 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2008 9 7 R108 Received 4 March 2008 Revised 31 May 2008 Accepted 8 July 2008 2008 Naxerova et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In recent years the molecular underpinnings of the long-observed resemblance between neoplastic and immature tissue have begun to emerge. Genome-wide transcriptional profiling has revealed similar gene expression signatures in several tumor types and early developmental stages of their tissue of origin. However it remains unclear whether such a relationship is a universal feature of malignancy whether heterogeneities exist in the developmental component of different tumor types and to which degree the resemblance between cancer and development is a tissue-specific phenomenon. Results We defined a developmental landscape by summarizing the main features of ten developmental time courses and projected gene expression from a variety of human tumor types onto this landscape. This comparison .