tailieunhanh - Báo cáo y học: "Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation. | Research Open Access Gene expression analysis of nuclear factor I-A deficient mice indicates delayed brain maturation Yong Wee Wong Christian Schulze Thomas StreicherC Richard M Gronostajski Melitta Schachner and Thomas Tilling Addresses Zentrum fur Molekulare Neurobiologie Hamburg Universitatsklinikum Hamburg-Eppendorf Martinistrasse 52 D-20246 Hamburg Germany. Hnstitut fur Klinische Chemie Universitatsklinikum Hamburg-Eppendorf Martinistrasse 52 D-20246 Hamburg Germany. Department of Biochemistry and Program in Neuroscience State University of New York at Buffalo 140 Farber Hall 3435 Main Street Buffalo NY 14214 USA. Keck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience Rutgers University 604 Allison Road D-251 Piscataway NJ 08854 USA. Correspondence Thomas Tilling. Email Published 2 May 2007 Received 2 February 2007 Genome Biology 2007 8 R72 doi gb-2007-8-5-r72 Accepted 2 May 2007 The electronic version of this article is the complete one and can be found online at http 2007 8 5 R72 2007 Wong et al licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Nuclear factor I-A NFI-A a phylogenetically conserved transcription replication protein plays a crucial role in mouse brain development. Previous studies have shown that disruption of the Nfia gene in mice leads to perinatal lethality corpus callosum agenesis and hydrocephalus. Results To identify potential NFI-A target genes involved in the observed tissue malformations we analyzed gene expression in brains from Nfia- - and Nfia littermate mice at the mRNA level using oligonucleotide microarrays. In young postnatal animals postnatal day 16 356 genes were .