tailieunhanh - Báo cáo y học: "Common gene expression strategies revealed by genome-wide analysis in yeast"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Common gene expression strategies revealed by genome-wide analysis in yeast. | Open Access Research Common gene expression strategies revealed by genome-wide analysis in yeast José García-Martínez Ý Fernando Gonzalez-Candelas and José E Pérez-Ortínỷ Addresses Sección de Chips de DNA-SCSIE Universitat de Valencia Dr Moliner 50 E-46100 Burjassot Spain. fDepartamento de Bioquímica y Biología Molecular Universitat de Valencia Dr Moliner 50 E-46100 Burjassot Spain. Instituto Cavanilles de Biodiversidad y Biología Evolutiva and Departamento de Genética Universitat de Valencia Dr Moliner 50 E-46100 Burjassot Spain. Correspondence José E Pérez-Ortín. Email Published 19 October 2007 Received 15 March 2007 Genome Biology 2007 8 R222 doi gb-2007-8-l0-r222 Revised j24 iuly 2007 gy g Accepted 19 October 2007 The electronic version of this article is the complete one and can be found online at http 2007 8 10 R222 2007 Garcia-Martinez et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Gene expression is a two-step synthesis process that ends with the necessary amount of each protein required to perform its function. Since the protein is the final product the main focus of gene regulation should be centered on it. However because mRNA is an intermediate step and the amounts of both mRNA and protein are controlled by their synthesis and degradation rates the desired amount of protein can be achieved following different strategies. Results In this paper we present the first comprehensive analysis of the relationships among the six variables that characterize gene expression in a living organism transcription and translation rates mRNA and protein amounts and mRNA and protein stabilities. We have used previously published data from exponentially .