Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans. | Open Access Parallel evolution of conserved non-coding elements that target a common set of developmental regulatory genes from worms to humans Tanya Vavouri Klaudia Walter Walter R Gilks Ben Lehner and Greg Elgar Addresses Wellcome Trust Sanger Institute Wellcome Trust Genome Campus Hinxton Cambridge CB10 1SA UK. School of Biological and Chemical Sciences Queen Mary University of London London E1 4NS UK. MRC Biostatistics Unit Institute of Public Health Cambridge CB2 2SR UK. Department of Statistics University of Leeds Leeds LS2 9JT UK. EMBL CRG Systems Biology Unit Centre for Genomic Regulation CRG UPF C Dr. Aiguader 88 Barcelona 08003 Spain. These authors contributed equally to this work. Correspondence Tanya Vavouri. Email tv1@sanger.ac.uk Published 2 February 2007 Genome Biology 2007 8 R15 doi l0.ll86 gb-2007-8-2-rl5 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 2 R15 2007 Vavouri et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Received 25 July 2006 Revised 20 October 2006 Accepted 2 February 2007 Abstract Background The human genome contains thousands of non-coding sequences that are often more conserved between vertebrate species than protein-coding exons. These highly conserved non-coding elements CNEs are associated with genes that coordinate development and have been proposed to act as transcriptional enhancers. Despite their extreme sequence conservation in vertebrates sequences homologous to CNEs have not been identified in invertebrates. Results Here we report that nematode genomes contain an alternative set of CNEs that share sequence characteristics but not identity with their vertebrate counterparts. CNEs thus represent a very .