tailieunhanh - Báo cáo y học: "Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Intensive insulin treatment improves forearm blood flow in critically ill patients: a randomized parallel design clinical trial. | Available online http content 13 6 R198 Open Access Research Intensive insulin treatment improves forearm blood flow in critically ill patients a randomized parallel design clinical trial Ivan Zuran1 Pavel Poredos2 Rafael Skale3 Gorazd Voga3 Lucija and Roman Pareznik3 1 Department of Angiology Endocrinology and Rheumatology General Hospital Celje Oblakova ul. 5 3000 Celje Slovenia 2Clinical Department of Vascular Diseases University Medical Centre Ljubljana Zaloska c. 2 1000 Ljubljana Slovenia Department of Intensive Internal Medicine General Hospital Celje Oblakova ul. 5 3000 Celje Slovenia Corresponding author Ivan Zuran Received 30 Jul 2009 Revisions requested 2 Sep 2009 Revisions received 8 Oct 2009 Accepted 9 Dec 2009 Published 9 Dec 2009 Critical Care 2009 13 R198 doi cc8202 This article is online at http content 13 6 R1 98 2009 Zuran et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Intensive insulin treatment of critically ill patients was seen as a promising method of treatment though recent studies showed that reducing the blood glucose level below 6 mmol l had a detrimental outcome. The mechanisms of the effects of insulin in the critically ill are not completely understood. The purpose of the study was to test the hypothesis that intensive insulin treatment may influence forearm blood flow independently of global hemodynamic indicators. Methods The study encompassed 29 patients of both sexes who were admitted to the intensive care unit due to sepsis and required artificial ventilation as the result of acute respiratory failure. 14 patients were randomly selected for intensive insulin treatment Group 1 blood glucose .