tailieunhanh - Báo cáo y học: "Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection. | Open Access Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection Nicoletta Bivi Milena Romanello Richard Harrison Ian Clarke David C Hoyle Luigi Moro Fulvia Ortolani Antonella Bonetti Franco Quadrifoglio Gianluca TellH and Daniela DelneriH Addresses Department of Biomedical Sciences and Technologies University of Udine Piazzale Kolbe 33100 Udine Italy. Taculty of Life Science University of Manchester Oxford Road M13 9PT Manchester UK. School of Biological Sciences Institute of Evolutionary Biology King s Buildings West Mains Road Edinburgh EH9 3JT UK. The Center for the Study of Metabolic Bone Diseases via Vittorio Veneto 34170 Gorizia Italy. Department of Medical and Morphological Research University of Udine Piazzale Kolbe 33100 Udine Italy. H These authors contributed equally to this work. Correspondence Daniela Delneri. Email Published 10 September 2009 Genome Biology 2009 10 R93 doi gb-2009- 10-9-r93 The electronic version of this article is the complete one and can be found online at http 2009 10 9 R93 Received 14 May 2009 Revised 16 July 2009 Accepted 10 September 2009 2009 Bivi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited Abstract Background Nitrogen-containing bisphosphonates are the elected drugs for the treatment of diseases in which excessive bone resorption occurs for example osteoporosis and cancer-induced bone diseases. The only known target of nitrogen-containing bisphosphonates is farnesyl pyrophosphate synthase which ensures prenylation of prosurvival proteins such as Ras. However it is likely that the action of nitrogen-containing .