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Báo cáo y học: "Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Differential gene expression patterns in cyclooxygenase-1 and cyclooxygenase-2 deficient mouse brain. | Open Access Research Differential gene expression patterns in cyclooxygenase-l and cyclooxygenase-2 deficient mouse brain Christopher D Toscano Vinaykumar V Prabhu Robert Langenbach Kevin G Becker and Francesca Bosetti Addresses Brain Physiology and Metabolism Section National Institute on Aging National Institutes of Health Bldg. 9 Rm. 1S126 9 Memorial Drive Bethesda Maryland 20892 USA. Gene Expression and Genomics Unit National Institute on Aging National Institutes of Health Gerontology Research Center 5600 Nathan Shock Drive Baltimore Maryland 21224 USA. Laboratory of Molecular Carcinogenesis National Institute of Environmental Health Sciences National Institutes of Health 111 TW Alexander Drive Research Triangle Park North Carolina 27709 USA. Correspondence Francesca Bosetti. Email frances@mail.nih.gov Published 31 January 2007 Genome Biology 2007 8 R14 doi l0.ll86 gb-2007-8-l-rl4 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2007 8 l Rl4 Received 24 August 2006 Revised 9 November 2006 Accepted 31 January 2007 2007 Toscano et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cyclooxygenase COX -l and COX-2 produce prostanoids from arachidonic acid and are thought to have important yet distinct roles in normal brain function. Deletion of COX-l or COX-2 results in profound differences both in brain levels of prostaglandin E2 and in activation of the transcription factor nuclear factor-KB suggesting that COX-l and COX-2 play distinct roles in brain arachidonic acid metabolism and regulation of gene expression. To further elucidate the role of COX isoforms in the regulation of the brain transcriptome microarray analysis of gene expression