tailieunhanh - Báo cáo y học: "Differential gene expression in anatomical compartments of the human eye"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Differential gene expression in anatomical compartments of the human eye. | Open Access Research Differential gene expression in anatomical compartments of the human eye Jennifer J Diehn Maximilian Diehn Michael F Marmor and Patrick O Brown 1 Addresses Department of Ophthalmology Stanford University School of Medicine Stanford CA 94305 USA. Department of Biochemistry Stanford University School of Medicine Stanford CA 94305 USA. Howard Hughes Medical Institute Stanford University School of Medicine Stanford CA 94305 USA. Department of Ophthalmology University of California San Francisco San Francisco CA 94143 USA. Correspondence Patrick O Brown. E-mail pbrown@ Published 17 August 2005 Received 10 May 2005 Genome Biology 2005 6 R74 doi l86 gb-2005-6-9-r74 Revised J5 JuJy .2005 Accepted 15 July 2005 The electronic version of this article is the complete one and can be found online at http 2005 6 9 R74 2005 Diehn et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The human eye is composed of multiple compartments diverse in form function and embryologic origin that work in concert to provide us with our sense of sight. We set out to systematically characterize the global gene expression patterns that specify the distinctive characteristics of the various eye compartments. Results We used DNA microarrays representing approximately 30 000 human genes to analyze gene expression in the cornea lens iris ciliary body retina and optic nerve. The distinctive patterns of expression in each compartment could be interpreted in relation to the physiology and cellular composition of each tissue. Notably the sets of genes selectively expressed in the retina and in the lens were particularly large and diverse. Genes with roles in immune defense .