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Báo cáo y học: "Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Minireview cung cấp cho các bạn kiến thức về ngành y đề tài: Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters. | Research Open Access Transcriptional and structural impact of TATA-initiation site spacing in mammalian core promoters Jasmina Ponjavic Boris Lenhard Chikatoshi Kai Jun Kawai Piero Carninci Yoshihide Hayashizaki and Albin Sandelin Addresses Genome Exploration Research Group Genome Network Project Core Group RIKEN Genomic Sciences Center GSC RIKEN Yokohama Institute Yokohama Kanagawa 230-0045 Japan. ỶMRC Functional Genetics Unit Department of Physiology Anatomy and Genetics University of Oxford Oxford OX1 3QX UK. Computational Biology Unit Bergen Center for Computational Science University of Bergen HIB Thormohlensgate 55 N-5008 Bergen Norway. Genome Science Laboratory Discovery and Research Institute RIKEN Wako Institute Wako Saitama 351-0198 Japan. Correspondence Albin Sandelin. Email rgscerg@gsc.riken.jp Published 17 August 2006 Genome Biology 2006 7 R78 doi 10.1 l86 gb-2006-7-8-r78 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2006 7 8 R78 Received 3 May 2006 Revised 19 June 2006 Accepted 17 August 2006 2006 Ponjavic et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The TATA box one of the most well studied core promoter elements is associated with induced context-specific expression. The lack of precise transcription start site TSS locations linked with expression information has impeded genome-wide characterization of the interaction between TATA and the pre-initiation complex. Results Using a comprehensive set of 5.66 X 106 sequenced 5 cDNA ends from diverse tissues mapped to the mouse genome we found that the TATA-TSS distance is correlated with the tissue specificity of the downstream transcript. To achieve tissue-specific .