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Báo cáo y học: "New animal models for evolution and development"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: New animal models for evolution and development. | Meeting report New animal models for evolution and development Kristin Tessmar-Raible and Detlev Arendt Address European Molecular Biology Laboratory Meyerhofstrasse 1 69012 Heidelberg Germany. E-mail tessmar@embl.de arendt@embl.de Published 21 December 2004 Genome Biology 2004 6 303 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2004 6 l 303 2004 BioMed Central Ltd A report on the annual UK Evolutionary Developmental Biology meeting Oxford UK 13 September 2004. To resolve the puzzle of metazoan evolution and development bioinformatic and experimental approaches must be applied to a wider range of species than just the standard model organisms. This was reflected in the list of phyla covered in this year s Evo-Devo meeting organized by David Ferrier and Peter Holland both at the University of Oxford UK . Much of our understanding of metazoan evolution and development evo-devo is based on comparisons of the model organisms Caenorhabditis elegans and Drosophila melanogaster with the vertebrates - but such comparisons have two main limitations. First they cannot tell us where metazoan genes come from or what their original role was in our unicellular ancestors. To try to answer this question the unicellular choanoflagellates have now come on to the molecular stage. Second evidence is accumulating that both Drosophila and C. elegans are fast-evolving organisms have lost many ancestral genes and have modified development more than other bilaterans. Needless to say this complicates evolutionary studies. The meeting drew our attention to studies on crustaceans the wasp Nasonia and the polychaete Platynereis that have shed new light on the evolution of segmentation axis formation and eye development respectively. Many genes in multicellular animals such as those for cell adhesion proteins intercellular signaling proteins extracellular matrix components and certain families of transcription factors have no .