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Báo cáo khoa học: "Appearance of EI: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Appearance of EI: A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreak | Virology Journal BioMed Central Open Access Study protocol Appearance of EI A226V mutant Chikungunya virus in Coastal Karnataka India during 2008 outbreak SR Santhosh Paban Kumar Dash Manmohan Parida Mohasin Khan and PVL Rao Address Division of Virology Defence R D Establishment DRDE Jhansi Road Gwalior MP India PIN - 474 002 Email SR Santhosh - santhuvet4u@rediffmail.com Paban Kumar Dash - pabandash@rediffmail.com Manmohan Parida - paridamm@rediffmail.com Mohasin Khan - mohasin@gmail.com PVL Rao - pvlrao@rediffmail.com Corresponding author Published 27 October 2009 Received 4 August 2009 Accepted 27 October 2009 Virology Journal 2009 6 172 doi 10.ll86 1743-422X-6-172 This article is available from http www.virologyj.com content 6 1 172 2009 Santhosh et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59 535 and 64 548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and the mutations involved are useful for further control measures. Among the 2008 outbreaks the Coastal Karnataka accounts for the 46 510 persons. An in-depth investigation of Chikungunya epidemic of Coastal Karnataka India 2008 by serology virus isolation RT-PCR and genome sequencing revealed the presence and continued circulation of A226V mutant Chikungunya virus. The appearance of this mutant virus was found to be associated with higher prevalence of vector Aedes albopictus