tailieunhanh - Báo cáo y học: " Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations | Theoretical Biology and Medical Modelling BioMed Central Research Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations Tinevimbo Shiri 1 2 and AlexWelte1 2 Open Access Address 1School of Computational and Applied Mathematics University of the Witwatersrand Private Bag 3 Johannesburg South Africa and 2South African Centre of Excellence in Epidemiological Modelling and Analysis SACEMA Stellenbosch University South Africa Email Tinevimbo Shiri - tshiri@ Alex Welte - Corresponding author Published 14 November 2008 Received 25 July 2008 Theoretical Biology and Medical Modelling 2008 5 25 doi 1742-4682-5-25 Accepted 14 November 2008 This article is available from http content 5 1 25 2008 Shiri and Welte licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Highly selective antiretroviral ARV regimens such as single dose nevirapine NVP used for prevention of mother to child transmission PMTCT in resource-limited settings produce transient increases in otherwise marginal subpopulations of cells infected by mutant genomes. The longer term implications for accumulation of further resistance mutations are not fully understood. Methods We develop a new strain-differentiated hybrid deterministic-stochastic population dynamic type model of healthy and infected cells. We explore how the transient increase in a population of cells transcribed with a common mutation modelled deterministically which occurs in response to a short course of monotherapy has an impact on the risk of appearance of rarer higher-order