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Báo cáo y học: "Changes in serum creatinine in the first 24 hours after cardiac arrest indicate prognosis: an observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Changes in serum creatinine in the first 24 hours after cardiac arrest indicate prognosis: an observational cohort study. | Available online http ccforum.eom content 13 5 R168 Research Changes in serum creatinine in the first 24 hours after cardiac arrest indicate prognosis an observational cohort study Dietrich Hasper1 Stephan von Haehling2 Christian Storm1 Achim Jorres1 and Joerg C Schefold1 1Charite-Universitatsmedizin Berlin Campus Virchow-Klinikum Department of Nephrology and Medical Intensive Care Augustenburger Platz 1 13353 Berlin Germany 2Charite-Universitatsmedizin Berlin Campus Virchow-Klinikum Department of Clinical Cardiology Augustenburger Platz 1 13353 Berlin Germany Corresponding author Dietrich Hasper dietrich.hasper@charite.de Received 16 Jul 2009 Revisions requested 2 Sep 2009 Revisions received 22 Sep 2009 Accepted 29 Oct 2009 Published 29 Oct 2009 Critical Care 2009 13 R168 doi 10.1186 cc8144 This article is online at http ccforum.com content 13 5 R1 68 2009 Hasper et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction As patients after cardiac arrest suffer from the consequences of global ischemia reperfusion we aimed to establish the incidence of acute kidney injury AKI in these patients and to investigate its possible association to severe hypoxic brain damage. Methods One hundred and seventy-one patients 135 male mean age 61.6 - 15.0 years after cardiac arrest were included in an observational cohort study. Serum creatinine was determined at admission and 24 48 and 72 hours thereafter. Serum levels of neuron-specific enolase NSE were measured 72 hours after admission as a marker of hypoxic brain damage. Clinical outcome was assessed at intensive care unit ICU discharge using the Pittsburgh cerebral performance category CPC . Results AKI as defined by AKI Network criteria occurred in 49 .