tailieunhanh - Báo cáo y học: "Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis. | Kapetanovic et al. Arthritis Research Therapy 2011 13 R31 http content 13 1 R31 RESEARCH ARTICLE Open Access Early changes in bone mineral density measured by digital X-ray radiogrammetry predict up to 20 years radiological outcome in rheumatoid arthritis 1 t 1t 2 3 T- - 1 1 Meliha C Kapetanovic Elisabet Lindqvist Jakob Algulin Kjell Jonsson Tore Saxne Kerstin Eberhardt and Pierre Geborek1 Abstract Introduction Changes in bone mineral density BMD in the hand as evaluated by digital X-ray radiogrammetry DXR of the second to fourth metacarpal bones has been suggested to predict future joint damage in patients with rheumatoid arthritis RA . This study s objective was to investigate whether DXR-BMD loss early in the course of the disease predicts the development of joint damage in RA patients followed for up to 20 years. Methods A total of 183 patients 115 women and 68 men with early RA mean disease duration 11 months included from 1985 to 1989 were followed prospectively the Lund early RA cohort . Clinical and functional measures were assessed yearly. Joint damage was evaluated according to the Larsen score on radiographs of the hands and feet obtained in years 0 to 5 and years 10 15 and 20. These radiographs were digitized and BMD of the second to fourth metacarpal bones was evaluated by DXR. Early DXR-BMD change rate that is bone loss per year calculated from the first two radiographs obtained on average 9 months apart SD were available for 135 patients. Mean values of the right and left hand were used. Results Mean early DXR-BMD loss during the first year calculated was g cm2 SD . Patients with marked bone loss that is early DXR-BMD loss above the median for the group had significantly worse progression of joint damage at all examinations during the 20-year period. Conclusions Early DXR-BMD progression rate predicted the development of joint damage evaluated according to Larsen score at year 1 and for up to 20 years in this .