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Báo cáo y học: " Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. | Available online http ccforum.eom content 13 3 R74 Research Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis Gisele P Oliveira1 Mariana BG Oliveira1 Raquel S Santos1 Leticia D Lima1 Cristina M Dias1 Alexandre M AB Saber2 Walcy R Teodoro2 Vera L Capelozzi2 Rachel N Gomes3 Patricia T Bozza3 Paolo Pelosi4 and Patricia RM Rocco1 Open Access Laboratory of Pulmonary Investigation Carlos Chagas Filho Institute of Biophysics Federal University of Rio de Janeiro Av. Carlos Chagas Filho s n Rio de Janeiro 21 949-902 Brazil 2Department of Pathology Faculty of Medicine University of São Paulo Dr. Arnaldo Street 455 Sao Paulo 01246-903 Brazil laboratory of Immunopharmacology Oswaldo Cruz Institute FIOCRUZ Avenida Brasil 4365 Rio de Janeiro 21045-900 Brazil 4Department of Ambient Health and Safety University of Insubria c o Villa Toeplitz Via G.B. Vico 46 21100 Varese Italy Corresponding author Patricia RM Rocco prmrocco@gmail.com Received 2 Apr 2009 Accepted 19 May 2009 Published 19 May 2009 Critical Care 2009 13 R74 doi 10.1186 cc7888 This article is online at http ccforum.com content 13 3 R74 2009 Oliveira et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The protective effect of glutamine as a pharmacological agent against lung injury has been reported in experimental sepsis however its efficacy at improving oxygenation and lung mechanics attenuating diaphragm and distal organ injury has to be better elucidated. In the present study we tested the hypothesis that a single early intravenous dose of glutamine was associated not only with the improvement of lung morpho-function but also the reduction of the inflammatory process and epithelial cell .