tailieunhanh - Báo cáo y học: "A simple intravenous glucose tolerance test for assessment of insulin sensitivity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A simple intravenous glucose tolerance test for assessment of insulin sensitivity. | Hahn et al. Theoretical Biology and Medical Modelling 2011 8 12 http content 8 1 12 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access A simple intravenous glucose tolerance test for assessment of insulin sensitivity Robert G Hahn1 2 Stefan Ljunggren2 3 Filip Larsen4 and Thomas Nystrom3 Correspondence . com 1Section for Anesthesia Faculty of Health Sciences Linkoping University Linkoping Sweden Full list of author information is available at the end of the article 2 BioMed Central Abstract Background The aim of the study was to find a simple intravenous glucose tolerance test IVGTT that can be used to estimate insulin sensitivity. Methods In 20 healthy volunteers aged between 18 and 51 years mean 28 comparisons were made between kinetic parameters derived from a 12-sample 75min IVGTT and the Mbw glucose uptake obtained during a hyperinsulinemic euglycemic glucose clamp. Plasma glucose was used to calculate the volume of distribution Vd and the clearance CL of the injected glucose bolus. The plasma insulin response was quantified by the area under the curve AUCins . Uptake of glucose during the clamp was corrected for body weight Mbw . Results There was a 7-fold variation in Mbw. Algorithms based on the slope of the glucose-elimination curve CL Vd in combination with AUCins obtained during the IVGTT showed statistically significant correlations with Mbw the linearity being r2 . The best algorithms were associated with a 25-75th prediction error ranging from -10 to 10 . Sampling could be shortened to 30-40 min without loss of linearity or precision. Conclusion Simple measures of glucose and insulin kinetics during an IVGTT can predict between 2 3 and 4 5 of the insulin sensitivity. Introduction The best established methods of measuring insulin resistance are the hyperinsulinemic euglycemic glucose clamp and the intravenous glucose tolerance test IVGTT of which former is the gold standard 1-3 . These methods have a long