tailieunhanh - Báo cáo y học: " Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV."

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV. | Mellberg et al. AIDS Research and Therapy 2011 8 21 http content 8 1 21 AIDS RESEARCH AND THERAPY RESEARCH Open Access Rebound of residual plasma viremia after initial decrease following addition of intravenous immunoglobulin to effective antiretroviral treatment of HIV Tnrntic l i ol I hard 1 or n i 3 Pi fC hnvolQ 2 Annirto I inrll x ici 3 Ar iH rHón1 AfiiHcirc Qnnnarhnrn3 4 lumdb Mellbeig Veionica D Gonzalez Al mica Lindkvisi Aivid Edcii Andeis Sunneiboig Johan K Sandbeig2 Bo Svenneiholm5 and Magnus Gisslén1 Abstract Background High dosage of intravenous immunoglobulin IVIG has been obseived as a possible activatoi of HIV gene expression in latently infected testing CD4 T-cells leading to a substantial decrease in both the tesetvoit and the residual plasma viremia when added to effective ART. IVIG treatment has also been reported to expand T iegulatoiy cells Tiegs . The aim of this study was to evaluate possible long-teim effect of IVIG treatment on residual viiemia and T-lymphocyte activation. Methods Nine HIV-infected subjects on effective ART included in a previously reported study on IVIG treatment weie evaluated 48-104 weeks aftei theiapy. In addition 14 HIV-infected controls on suppressive ART weie included. HIV-1 RNA was analyzed in cell-fiee plasma by using an ultrasensitive PCR-method with a detection limit of 2 copies mL. T-lymphocyte activation maikeis and seium inteileukins weie measured. Results Plasma residual viiemia rebounded to pie-tieatment levels 48-104 weeks aftei the initial deciease that was obseived following treatment with high-dosage IVIG. No long-teim effect was obseived iegaiding T-lymphocyte activation maikeis T-iegulatoiy cells oi seium inteileukins. In a post-hoc analysis a coiielation between plasma HIV-1-RNA and CD4 T-cell count was found in both IVIG-tieated patients and controls. Conclusions These results indicate that the deciease in the latent HIV-1 pool obseived duiing IVIG treatment is transient. .