tailieunhanh - Báo cáo y học: " Intravenous magnesium in subarachnoid hemorrhage"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Intravenous magnesium in subarachnoid hemorrhage. | Abdo et al. Critical Care 2011 15 427 http content 15 3 427 CRITICAL CARE LETTER L_ Intravenous magnesium in subarachnoid hemorrhage Wilson F Abdo Cornelia W Hoedemaekers and Johannes G van der Hoeven See related research by Wong etal. http content 15 1 R52 We would like to offer some comments on the updated meta-analysis on intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage 1 which was conducted by Wong and colleagues and published in a recent issue of Critical Care. First the authors did not mention a non-blinded randomized placebo-controlled trial conducted by Akdemir and colleagues and published in 2009 2 . Although this study would probably not pass Wong and colleagues method of scrutiny we believe that it should be mentioned alongside two other studies the authors described but did not include in the data analysis. Second the study by Westermaier and colleagues 3 should not be included in the data analysis. These authors in contrast to those of the other included studies in which magnesium was used as an add-on therapy did not use nimodipine in any of the included patients. Wong and colleagues exclude the study by Schmid-Elsaesser and colleagues 4 because nimodipine was not used in the magnesium group but omit doing the same for the study by Westermaier and colleagues. Third Figure 3 1 shows that the number of control subjects in Veyna 2002 was 20. However in that study the outcome data in the control group were present for only 16 patients 4 of the 20 patients were withdrawn because study requirements were not met 5 . Accordingly the risk ratios in Figure 3 should be adjusted. Fourth given Wong and colleagues definition of delayed cerebral ischemia we wonder why the studies of Veyna and colleagues 5 Muroi and colleagues 6 and their own study in 2006 7 were not included in Figure 1 1 . In the study by Veyna and colleagues 5 the outcome measure clinical vasospasm was defined as a new focal neurological deficit .