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Báo cáo y học: "Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides | Retrovirology BioMed Central Research Open Access Inhibition of early steps in the lentiviral replication cycle by cathelicidin host defense peptides Lars Steinstraesser 1 Bettina Tippler2 Janine Mertens1 Evert Lamme3 Heinz-Herbert Homann1 Marcus Lehnhardt1 Oliver Wildner2 Hans- Ulrich Steinau1 and Klaus uberla2 Address Department for Plastic Surgery BG University Hospital Bergmannsheil Ruhr University Bochum Buerkle-de-la- Camp Platz 1 44789 Bochum Germany 2Department of Molecular and Medical Virology Ruhr University Bochum Universitatsstrafie 150 44801 Bochum Germany and 3Department of Dermatology University Medical Center Nijmegen Geert Grooteplein 9 6525 GA Nijmegen Netherlands Email Lars Steinstraesser - lars.steinstraesser@ruhr-uni-bochum.de Bettina Tippler - bettina.tippler@ruhr-uni-bochum.de Janine Mertens - janine.mertens@ruhr-uni-bochum.de Evert Lamme - e.lamme@derma.umcn.nl Heinz- Herbert Homann - Heinz.Homann@ruhr-uni-bochum.de Marcus Lehnhardt - marcus.lehnhardt@ruhr-uni-bochum.de Oliver Wildner - oliver.wildner@ruhr-uni-bochum.de Hans-Ulrich Steinau - hans-ulrich.steinau@bergmannsheil.de Klaus uberla - klaus.ueberla@ruhr-uni-bochum.de Corresponding author Published 18 January 2005 Received 10 December 2004 Accepted 18 January 2005 Retrovirology 2005 2 2 doi l0.ll 86 1742-4690-2-2 This article is available from http www.retrovirology.cOm content 2 1 2 2005 Steinstraesser et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The antibacterial activity of host defense peptides HDP is largely mediated by permeabilization of bacterial membranes. The lipid membrane of enveloped viruses might also be a target of antimicrobial peptides. Therefore we screened a panel of naturally occurring HDPs .