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Báo cáo y học: " Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous (ductal plate malformation) fetal liver"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous (ductal plate malformation) fetal liver. | Comparative Hepatology BioMed Central Research Immunohistochemical study of the phenotypic change of the mesenchymal cells during portal tract maturation in normal and fibrous ductal plate malformation fetal liver Julien Villeneuve1 Fanny Pelluard-Nehme2 Chantal Combe1 Dominique Carles2 Christine Chaponnier3 Jean Ripoche1 Charles Balabaud1 Paulette Bioulac-Sage1 2 and Sébastien Lepreux 1 2 Address 1INSERM U889 Université Bordeaux2 F-33076 Bordeaux France 2Service d Anatomie Pathologique Hôpital Pellegrin F-33076 Bordeaux France and 3Département de Pathologie et d lmmunologie CMU Genève Suisse Email Julien Villeneuve - julienvilleneuve27@hotmail.com Fanny Pelluard-Nehme - fanny.pelluard-nehme@chu-bordeaux.fr Chantal Combe - chantal.combe@bordeaux.inserm.fr Dominique Carles - dominique.carles@chu-bordeaux.fr Christine Chaponnier - Christine.Chaponnier@medecine.unige.ch Jean Ripoche - jean.ripoche@gref.u-bordeaux.fr Charles Balabaud - charles.balabaud@chu-bordeaux.fr Paulette Bioulac-Sage - paulette.bioulac-sage@chu-bordeaux.fr Sébastien Lepreux - sebastien.lepreux@chu-bordeaux.fr Corresponding author Open Access Published 14 July 2009 Comparative Hepatology 2009 8 5 doi 10.1186 1476-5926-8-5 Received 1 February 2009 Accepted 14 July 2009 This article is available from http www.comparative-hepatology.cOm content 8 1 5 2009 Villeneuve et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In adult liver the mesenchymal cells portal fibroblasts and vascular smooth muscle cells can transdifferentiate into myofibroblasts and are involved in portal fibrosis. Differential expression of markers such as alpha-smooth muscle actin ASMA h-caldesmon and cellular retinol-binding protein-1 allows their phenotypic .