tailieunhanh - Báo cáo khoa học: "Immunohistochemical Study of the Pancreatic Endocrine Cells inthe BALB/c mice: An Unique Distributional Pattern of Glucagon"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Immunohistochemical Study of the Pancreatic Endocrine Cells inthe BALB/c mice: An Unique Distributional Pattern of Glucagon | J. Vet. Sci. 2002 3 3 167-173 JOURNAL OF Veterinary Science Immunohistochemical Study of the Pancreatic Endocrine Cells in the BALB c mice An Unique Distributional Pattern of Glucagon Sae-Kwang Ku Hyeung-Sik Lee1 and Jae-Hyun Lee2 Pharmacology Toxicology Laboratory Central Research Laboratories Dong-Wha Pharm. Ind. Co. 1 Department of Biology Faculty of Natural Sciences Kyungsan University Department of Histology College of Veterinary Medicine Kyungpook National University Received May 29 2002 Accepted July 15 2002 Abstract The regional distribution and relative frequency of insulin- glucagon- somatostatin- and pancreatic polypeptide PP -producing endocrine cells in the pancreas of BALB c mouse were investigated by immunohistochemical method. The pancreas of mice was divided into two portions pancreatic islets and exocrine portions and pancreatic islets were further subdivided into two regions central and peripheral regions and the relative frequency and regional distribution of immunoreactive cells against insulin glucagon somatostatin and PP antisera were monitored. In the pancreatic islet portions insulin-immunoreactive cells were located in the central regions and they were randomly dispersed in the whole pancreatic islets in some case of the small islets. Quite different from those of other mammals glucagon-immunoreactive cells were dispersed throughout central to peripheral regions in case of large islets and in the smaller ones most of these cells were situated in the peripheral regions. Somatostatin-immunoreactive cells were detected in the peripheral regions with various frequencies. Although some cells were demonstrated in the central regions of pancreatic islets most of PP-immunoreactive cells were located in the peripheral regions. In the exocrine portions all four types of immunoreactive cells were demonstrated in the BALB c mouse. Some peculiar distributional patterns of pancreatic endocrine cells were found in BALB c mouse especially in case of .