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Lecture Microbiology - Chapter 23: Cardiovascular, lymphatic and systemic diseases

Lecture Microbiology - Chapter 23: Cardiovascular, lymphatic and systemic diseases. This chapter presents the following content: Anatomy review, bacterial septicemias, streptococcal diseases, subacute bacterial endocarditis, bacterial systemic – plague, plague types,. | CARDIOVASCULAR, LYMPHATIC AND SYSTEMIC DISEASES CHAPTER 23 Copyright © 2012 John Wiley & Sons, Inc. All rights reserved. Anatomy Review Heart – Endocardium – Myocardium – Pericardium Blood Vessels – Arteries – Veins – Lymphatics Blood © 2012 John Wiley & Sons, Inc. All rights reserved. Bacterial Septicemias Septicemia (bacteria multiplying in blood) – Lymphangitis – Commonly Gram –ve – Pseudomonas – Serratia – Proteus Septic shock may be lethal – 50-70% death rate © 2012 John Wiley & Sons, Inc. All rights reserved. Streptococcal Diseases Puerperal Fever (Childbirth fever) – Streptococcus pyogenes (Group A) – Poor asepsis after childbirth or abortion – Microbes enter uterus – Penicillin usually effective, slow recovery Group B Streptococcal Disease – Streptococcus agalactiae – Neonatal sepsis/ meningitis – Common in vaginal microflora, testing is recommended in 3rd trimester © 2012 John Wiley & Sons, Inc. All rights reserved. Streptococcal Diseases (2) Rheumatic Fever – Autoimmune disease – Crossreactivity between S. pyogenes Ag and tissue Ag – Usually affects age 5-15 year olds – Genetic predisposition is suspected – HLA Ag seen in 75% of patients but 12% of population – Heart valve scarring can lead to permanent stenosis Endocarditis (SBE) – S. pyogenes focal infection – Targets those with scarred or deformed heart valves – May create biofilms on pacemakers – Prophylactic antibiotics before surgeries © 2012 John Wiley & Sons, Inc. All rights .