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Báo cáo khoa học: Nuclear World

The Saccharomyces cerevisiae gene CSM1(SPO86, YCR086w) encodes a protein involved in sporulation - a process equivalent to gametogenesis in higher organisms. Sporulation is part of the yeast life cycle, tightly coupled to such processes as mitosis and meiosis, cell cycle control, genome stability, nutritional control, cell wall morphogenesis, or and intracellular transport. | Nuclear World Abstracts Nuclear World A1-1 Interactions of Csm1 a protein essential for sporulation of the yeast Saccharomyces cerevisiae M. Wysocka-Kapcinska and J. Rytka Department of Genetics Institute of Biochemistry and Biophysics Polish Academy of Sciences Warsaw POLAND The Saccharomyces cerevisiae gene CSM1 SPO86 YCR086w encodes a protein involved in sporulation - a process equivalent to gametogenesis in higher organisms. Sporulation is part of the yeast life cycle tightly coupled to such processes as mitosis and meiosis cell cycle control genome stability nutritional control cell wall morphogenesis or and intracellular transport. Deletion of CSM1 leads to decreased sporulation efficiency malformation of spores and stoppage of spore germination. Csm1p was identified as a component of the monopolin complex which associates with kinetochores during meiosis I and prevents sister kinetochore bi-orientation Rabitsch et al. 2003 . Our results indicated a role of Csm1p in early steps of premeiotic DNA replication Wysocka et al. 2004 . The presented data on the identification of proteins associated with histidine-tagged Csm1p in a pull-down assay indicate that Csm1p is a component of a number of functionally connected protein complexes. The proteins classified as associated with Csm1p belong to functional families involved in sporulation intracellular transport cytoskeleton organization and cellular morphogenesis. A1-2 Arabidopsis EST1 SMG7-like protein is a novel regulator of meiotic cell cycle progression N. Riehs1 S. Akimcheva1 P. Bulankova1 R. Idol2 J. Siroky3 D. Shippen2 D. Schweizer1 and K. Riha1 1Gregor Mendel Institute of Molecular Plant Biology Vienna AUSTRIA 2Department of Biochemistry Biophysics Texas A M University College Station TX USA Institute of Biophysics Czech Academy of Sciences Brno CZECH REPUBLIC Cell cycle progression is regulated via the oscillating levels of specific cyclins that bind and thus activate cyclin dependent kinases CDK . The .