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Báo cáo khoa học: The nuclear lamina Both a structural framework and a platform for genome organization

The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina consisting of a one-layered network of intermediate filaments inter-connecting with a complex set of transmembrane proteins and chromatin associating factors. The constituent proteins, the lamins, have recently gained tremendous recognition, because mutations in the lamin A gene, | ễFEBS Journal MINIREVIEW The nuclear lamina Both a structural framework and a platform for genome organization Joanna M. Bridger1 Nicole Foeger2 Ian R. Kill1 and Harald Herrmann3 1 Centre for Celland Chromosome Biology Division of Biosciences BrunelUniversity London UK 2 Institute for MedicalBiochemistry Vienna Biocenter Austria 3 FunctionalArchitecture of the Cell German Cancer Research Center DKFZ Heidelberg Germany Keywords chromosomalorganization fluorescence in situ hybridization intermediate filaments lamins nuclear envelope Correspondence H. Herrmann B065 FunctionalArchitecture of the Cell German Cancer Research Center DKFZ Im Neuenheimer Feld 580 D-69120 Heidelberg Germany Fax 49 62214 23519 Tel 49 62214 23512 E-mail h.herrmann@dkfz-heidelberg.de Received 26 February 2006 accepted 8 January 2007 doi 10.1111 j.1742-4658.2007.05694.x The inner face of the nuclear envelope of metazoan cells is covered by a thin lamina consisting of a one-layered network of intermediate filaments interconnecting with a complex set of transmembrane proteins and chromatin associating factors. The constituent proteins the lamins have recently gained tremendous recognition because mutations in the lamin A gene LMNA are the cause of a complex group of at least 10 different diseases in human including the Hutchinson-Gilford progeria syndrome. The analysis of these disease entities has made it clear that besides cytoskeletal functions the lamina has an important role in the behaviour of the genome and is probably as a consequence of this function intimately involved in cell fate decisions. Furthermore these functions are related to the involvement of lamins in organizing the position and functional state of interphase chromosomes as well as to the occurrence of lamins and lamina-associated proteins within the nucleoplasm. However the structural features of these lamins and the nature of the factors that assist them in genome organization present an exciting challenge to modern .