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Báo cáo y học: "Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects"

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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects | BioMed Central BMC Psychiatry Research article Open Access Effects of typical and atypical antipsychotic drugs on gene expression profiles in the liver of schizophrenia subjects Kwang H Choi 1 Brandon W Higgs2 Serge Weis1 3 Jonathan Song1 Ida C Llenos1 3 Jeannette R Dulay1 3 Robert H Yolken4 and Maree J Webster1 Address 1 Stanley Laboratory of Brain Research Rockville MD 20850 USA 2Elashoff Consulting Redwood City CA 94065 USA Departments of Psychiatry and Pathology Uniformed Services University of the Health Sciences Bethesda MD 20814 USA and 4Stanley Laboratory of Developmental Neurovirology Johns Hopkins University School of Medicine 600 North Wolfe Street Blalock 1105 Baltimore MD 21287 USA Email Kwang H Choi - choik@stanleyresearch.org Brandon W Higgs - bhiggs100@yahoo.com Serge Weis - smjweis@yahoo.com Jonathan Song - sjonathan@comcast.net Ida C Llenos - icollenos@yahoo.com Jeannette R Dulay - jemanget@yahoo.com Robert H Yolken - rhyolken@aol.com Maree J Webster - websterm@stanleyresearch.org Corresponding author Published 16 September 2009 Received 18 March 2009 Accepted 16 September 2009 BMC Psychiatry 2009 9 57 doi l0.ll86 l47l-244X-9-57 p p This article is available from http www.biomedcentral.cOm l47l-244X 9 57 2009 Choi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Although much progress has been made on antipsychotic drug development precise mechanisms behind the action of typical and atypical antipsychotics are poorly understood. Methods We performed genome-wide expression profiling to study effects of typical antipsychotics and atypical antipsychotics in the postmortem liver of schizophrenia .

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