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Báo cáo y học: "Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Borna disease virus (BDV) circulating immunocomplex positivity in addicted patients in the Czech Republic: a prospective cohort analysis | Patel et al. BMC Psychiatry 2010 10 68 http www.biomedcentral.com 1471-244X 10 68 BMC Psychiatry CASE REPORT Open Access Acetylcholinesterase Inhibitors AChEI s for the treatment of visual hallucinations in schizophrenia a case report Sachin S Patel1 Azizah Attard1 Pamela Jacobsen1 Sukhi Shergill2 Abstract Background Visual hallucinations are commonly seen in various neurological and psychiatric disorders including schizophrenia. Current models of visual processing and studies in diseases including Parkinsons Disease and Lewy Body Dementia propose that Acetylcholine Ach plays a pivotal role in our ability to accurately interpret visual stimuli. Depletion of Ach is thought to be associated with visual hallucination generation. AchEI s have been used in the targeted treatment of visual hallucinations in dementia and Parkinson s Disease patients. In Schizophrenia it is thought that a similar Ach depletion leads to visual hallucinations and may provide a target for drug treatment Case Presentation We present a case of a patient with Schizophrenia presenting with treatment resistant and significantly distressing visual hallucinations. After optimising treatment for schizophrenia we used Rivastigmine an AchEI as an adjunct to treat her symptoms successfully. Conclusions This case is the first to illustrate this novel use of an AchEI in the targeted treatment of visual hallucinations in a patient with Schizophrenia. Targeted therapy of this kind can be considered in challenging cases although more evidence is required in this field. Background Visual hallucinations occur in a variety of neurological and psychiatric disorders and are prominent in the dementias and psychotic illness. The treatment of this distressing symptom often targets the underlying illness rather than the symptom. The pathophysiology of visual hallucinatory generation however remains unclear and more recent research has focused on acetylcholine depletion and its association with visual hallucinations.