tailieunhanh - Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Ovariectomized rats as a model of postmenopausal osteoarthritis: validation and application. | Available online http content 6 2 R169 Research article Open Access Ovariectomized rats as a model of postmenopausal osteoarthritis validation and application Pernille Hoegh-Andersen1 László B Tankó2 Thomas L Andersen1 Carina V Lundberg1 John A Mo1 Anne-Marie Heegaard1 Jean-Marie Delaissé1 and Stephan Christgau1 1Nordic Bioscience A S Herlev Hovedgade 207 2730 Herlev Denmark 2Center for Clinical and Basic Research Ballerup Byvej 222 2750 Ballerup Denmark Corresponding author Pernille Hoegh-Andersen e-mail pha@ Received 17 Oct 2003 Revisions requested 31 Oct 2003 Revisions received 14 Jan 2004 Accepted 21 Jan 2004 Published 19 Feb 2004 Arthritis Res Ther 2004 6 R169-R180 DOI ar1152 2004 Hoegh-Andersen et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract We aimed to assess the effect of ovariectomy on cartilage turnover and degradation to evaluate whether ovariectomized OVX rats could form an experimental model of postmenopausal osteoarthritis. The effect of ovariectomy on cartilage was studied using two cohorts of female Sprague-Dawley rats aged 5 and 7 months. In a third cohort the effect of exogenous estrogen and a selective estrogen receptor modulator was analyzed. Knee joints were assessed by histological analysis of the articular cartilage after 9 weeks. Cartilage turnover was measured in urine by an immunoassay specific for collagen type II degradation products CTX-II and bone resorption was quantified in serum using an assay for bone collagen type I fragments CTX-I . Surface erosion in the cartilage of the knee was more severe in OVX rats than in sham-operated animals particularly in the 7-month-old cohort P . Ovariectomy also significant increased CTX-I and CTX-II. Both .