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Báo cáo y học: "Bench-to-bedside review: Mechanisms and management of hyperthermia due to toxicity"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Bench-to-bedside review: Mechanisms and management of hyperthermia due to toxicity. | Available online http ccforum.eom content 11 6 236 Review Bench-to-bedside review Mechanisms and management of hyperthermia due to toxicity Florian Eyer and Thomas Zilker Department of Clinical Toxicology II Medizinische Klinik Klinikum rechts der Isar Technical University D-81675 Munich Germany Corresponding author Florian Eyer Florian.Eyer@t-online.de Published 6 December 2007 This article is online at http ccforum.com content 11 6 236 2007 BioMed Central Ltd Critical Care 2007 11 236 doi 10.1186 cc6177 Abstract Body temperature can be severely disturbed by drugs capable of altering the balance between heat production and dissipation. If not treated aggressively these events may become rapidly fatal. Several toxins can induce such non-infection-based temperature disturbances through different underlying mechanisms. The drugs involved in the eruption of these syndromes include sympatho-mimetics and monoamine oxidase inhibitors antidopaminergic agents anticholinergic compounds serotonergic agents medicaments with the capability of uncoupling oxidative phosphorylation inhalation anesthetics and unspecific agents causing drug fever. Besides centrally disturbed regulation disorders hyperthermia often results as a consequence of intense skeletal muscle hypermetabolic reaction. This leads mostly to rapidly evolving muscle rigidity extensive rhabdomyolysis electrolyte disorders and renal failure and may be fatal. The goal of treatment is to reduce body core temperature with both symptomatic supportive care including active cooling and specific treatment options. Introduction Body temperature regulation is complex and requires a balance between heat production and dissipation. Hyperthermia occurs when metabolic heat production exceeds heat dissipation. Many exogenously administered drugs are capable of altering the body s ability to maintain a constant temperature. Normal body temperature is approximately 37.0 C although this varies with the time of day. The Society of .