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Báo cáo y học: " A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: A peptide-loaded dendritic cell based cytotoxic T-lymphocyte (CTL) vaccination strategy using peptides that span SIV Tat, Rev, and Env overlapping reading frames | Retrovirology BioMed Central Research Open Access A peptide-loaded dendritic cell based cytotoxic T-lymphocyte CTL vaccination strategy using peptides that span SIV Tat Rev and Env overlapping reading frames Zachary Klase11 Michael J Donio11 Andrew Blauvelt3 4 5 Preston A Marx6 Kuan-Teh Jeang7 and Stephen M Smith 1 2 Address Department of Infectious Diseases Saint Michael s Medical Center Newark New Jersey USA 2Department of Preventive Medicine and Community Health New Jersey Medical School Newark New Jersey USA 3Department of Dermatology Oregon Health Science University Portland Oregon USA 4Department of Molecular Microbiology and Immunology Oregon Health Science University Portland Oregon USA 5Dermatology Service VA Medical Center Portland Oregon USA 6Tulane National Primate Research Center Tulane University Health Sciences Center Department ofTropical Medicine Covington Louisiana USA and 7Molecular Virology Section Laboratory of Molecular Medicine NIAID NIH Bethesda Maryland USA Email Zachary Klase - zklase@gwu.edu Michael J Donio - mikedonio@aol.com Andrew Blauvelt - blauvela@ohsu.edu Preston A Marx - pmarx@tulane.edu Kuan-Teh Jeang - KJEANG@niaid.nih.gov Stephen M Smith - ssmith1824@aol.com Corresponding author fEqual contributors Published 06 January 2006 Received 16 August 2005 Accepted 06 January 2006 Retrovirology 2006 3 1 doi l0.ll86 1742-4690-3-1 This article is available from http www.retrovirology.cOm content 3 1 1 2006 Klase et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract CTL based vaccine strategies in the macaque model of AIDS have shown promise in slowing the progression to disease. However rapid CTL escape viruses can emerge rendering such vaccination useless. We hypothesized that such .