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Báo cáo y học: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Human T-cell leukemia virus type I (HTLV-I) infection and the onset of adult T-cell leukemia (ATL). | Retrovirology BioMed Central Review Open Access Human T-cell leukemia virus type I HTLV-I infection and the onset of adult T-cell leukemia ATL Masao Matsuoka Address Institute for Virus Research Kyoto University Kyoto 606-8507 Japan Email Masao Matsuoka - mmatsuok@virus.kyoto-u.ac.jp Corresponding author Published 26 April 2005 Retrovirology 2005 2 27 doi 10.1186 1742-4690-2-27 Received 29 March 2005 Accepted 26 April 2005 This article is available from http www.retrovirology.cOm content 2 1 27 2005 Matsuoka licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The clinical entity of adult T-cell leukemia ATL was established around 1977 and human T-cell leukemia virus type 1 HTLV-I was subsequently identified in 1980. In the 25 years since the discovery of HTLV-I HTLV-I infection and its associated diseases have been extensively studied and many of their aspects have been clarified. However the detailed mechanism of leukemogenesis remains unsolved yet and the prognosis of ATL patients still poor because of its resistance to chemotherapy and immunodeficiency. In this review I highlight the recent progress and remaining enigmas in HTLV-I infection and its associated diseases especially ATL. Background In 1977 Takatsuki et al. reported adult T-cell leukemia ATL as a distinct clinical entity 1-3 . This disease is characterized by its aggressive clinical course infiltrations into skin liver gastrointestinal tract and lung hypercalcemia and the presence of leukemic cells with multilobulated nuclei flower cell Figure 1 . In 1980 Poiesz et al. discovered a human retrovirus in a cell line derived from a patient with ATL and designated it human T-cell leukemia virus type I HTLV-I 4 5 . The linkage between ATL and HTLV-I was proven