tailieunhanh - Báo cáo y học: "Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis. | Available online http content 8 4 R91 Research article Human viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis Annahita Keravala Eric R Lechman Joan Nash Zhibao Mi and Paul D Robbins Open Access Department of Molecular Genetics and Biochemistry University of Pittsburgh School of Medicine Pittsburgh PA 15261 USA Corresponding author Paul D Robbins probb@ Received 17 Jan 2006 Revisions requested 21 Feb 2006 Revisions received 12 Mar 2006 Accepted 20 Apr 2006 Published 16 May 2006 Arthritis Research Therapy 2006 8 R91 doi ar1 960 This article is online at http content 8 4 R91 2006 Keravala et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract IL-10 is a Th2 cytokine important for inhibiting cell-mediated immunity while promoting humoral responses. Human IL-10 hIL-10 has anti-inflammatory immunosuppressive as well as immunostimulatory characteristics whereas viral IL-10 vIL-10 a homologue of hIL-10 encoded by Epstein Barr virus EBV lacks several immunostimulatory functions. The immunostimulatory characteristic of hIL-10 has been attributed to a single amino acid isoleucine at position 87 which in vIL-10 is alanine. A mutant hIL-10 in which isoleucine has been substituted is biologically active with only immunosuppressive but not immunostimulatory functions making it a potentially superior therapeutic for inflammatory diseases. To compare the efficacy of with hIL-10 and vIL-10 in blocking the progression of rheumatoid arthritis we used replication defective adenoviral vectors to deliver .