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Báo cáo khoa học: "To be or not to be protease activated receptor-1 in activated protein C-initiated endothelial barrier protection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: To be or not to be protease activated receptor-1 in activated protein C-initiated endothelial barrier protection? | Available online http ccforum.eom content 11 1 407 Letter To be or not to be protease activated receptor-1 in activated protein C-initiated endothelial barrier protection Shi-Sheng Li Department of Molecular Experimental Medicine The Scripps Research Institute 10550 North Torrey Pines Road La Jolla CA 92037 USA Corresponding author Shi-Sheng Li sshli@scripps.edu Published 19 February 2007 This article is online at http ccforum.com content 11 1 407 2007 BioMed Central Ltd Critical Care 2007 11 407 doi 10.1186 cc5149 See related review by Looney and Matthay http ccforum.com content 10 6 239 The review by Looney and Matthay summarized recent progress in basic and preclinical research of activated protein C APC a novel therapeutic agent for the treatment of severe sepsis 1 . APC is traditionally an anticoagulant and profibrinolytic agent and has been appreciated to possess anti-inflammatory and anti-apoptotic properties yet the exact mechanisms by which APC executes its clinical effects in sepsis are not defined 2 . Emerging evidence has suggested that APC might exert its clinical benefit at least in part by maintaining endothelial barrier function 3 4 . The authors reviewed conflicting results of endothelial barrier protection of APC in the literature and pointed out that caution must be taken to interpret cell culture experiments and their relationship to in vivo conditions. Indeed one should exercise caution while reviewing controversial data. Looney and Matthay stated that in two different in vitro investigations 3 4 APC promoted endothelial barrier protection in a PAR-1- and S1 P1-dependent mechanism which represents a misinterpretation. These two papers did conclude that APC enhanced endothelial barrier function in different cell lines by a sphingosine 1-phosphate receptor-1 S1P1 -dependent signaling pathway but it is still arguable whether this is protease activated receptor-1 PAR-1 dependent. Finigan and colleagues showed that anti-PAR-1 blocking antibody did .