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Báo cáo y học: "Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge. | Kumar et al. Retrovirology 2010 7 49 http www.retrovirology.eom content 7 1 49 gtr RETR0VIR0L0GY RESEARCH Open Access Prior mucosal exposure to heterologous cells alters the pathogenesis of cell-associated mucosal feline immunodeficiency virus challenge Surender B Kumar 1 2 3 Sarah Leave 1 2 Kyle Porter4 Barnabe D Assogba1 2 3 and Mary J Burkhard1 2 3 Abstract Background Several lines of research suggest that exposure to cellular material can alter the susceptibility to infection by HIV-1. Because sexual contact often includes exposure to cellular material we hypothesized that repeated mucosal exposure to heterologous cells would induce an immune response that would alter the susceptibility to mucosal infection. Using the feline immunodeficiency virus FIV model of HIV-1 mucosal transmission the cervicovaginal mucosa was exposed once weekly for 12 weeks to 5 000 heterologous cells or media control and then cats were vaginally challenged with cell-associated or cell-free FIV. Results Exposure to heterologous cells decreased the percentage of lymphocytes in the mucosal and systemic lymph nodes LN expressing L-selectin as well as the percentage of CD4 CD25 T cells. These shifts were associated with enhanced ex-vivo proliferative responses to heterologous cells. Following mucosal challenge with cell-associated but not cell-free FIV proviral burden was reduced by 64 in cats previously exposed to heterologous cells as compared to media exposed controls. Conclusions The pathogenesis and or the threshold for mucosal infection by infected cells but not cell-free virus can be modulated by mucosal exposure to uninfected heterologous cells. Background In the early 1990s immunization against major histocompatibility complex MHC alloantigens was proposed as a potential human immunodeficiency virus HIV -1 vaccine strategy 1 . Recently interest in the potential of alloprotection against HIV-1 transmission has gained new momentum with the findings that allogeneic mismatch may be .