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Báo cáo y học: "Ocular pathology of uncommon hematologic malignancies: a case series"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Ocular pathology of uncommon hematologic malignancies: a case series. | Journal of Medical Case Reports BioMed Central Open Access Case report Ocular pathology of uncommon hematologic malignancies a case series James E Head1 2 Defen Shen1 Maribel Santiago-Maysonet1 Rachel J Bishop3 and Chi-Chao Chan 1 Address 1Immunopathology Section National Institutes of Health Bethesda MD USA 2Clinical Research Training Program NIH Bethesda MD USA and 3Consult Services Section National Eye Institute National Institutes of Health Bethesda MD USA Email James E Head - headj@od.nih.gov Defen Shen - dshen@nei.nih.gov Maribel Santiago-Maysonet - santiagom@nei.nih.gov Rachel J Bishop - bishopra@nei.nih.gov Chi-Chao Chan - chanc@nei.nih.gov Corresponding author Published 28 November 2007 Received 6 June 2007 - . J. . .lrn J m Accepted 28 November 2007 Journal of Medical Case Reports 2007 1 158 doi l0.ll86 l 752-1947-1-158 This article is available from http www.jmedicalcasereports.com content 1 1 158 2007 Head et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In general ocular complications of hematologic malignancies such as leukemia are well documented. However reports of ocular involvement in such diseases as lymphomatoid granulomatosis and chronic myelomonocytic leukemia are uncommon. Here we present cases of these two relatively rare hematologic malignancies demonstrating clinical and subclinical ocular involvement. Case Presentation In the first case a 54-year-old man with a previous diagnosis of lymphomatoid granulomatosis presented with a new-onset conjunctival lesion while his systemic disease was thought to be in remission. A biopsy was taken that revealed heavy infiltrates of B and T cells at the site of the lesion. Molecular analysis confirmed that these cells were positive for