tailieunhanh - Báo cáo y học: "Ocular Manifestations of West Nile Virus Infection"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Ocular Manifestations of West Nile Virus Infection. | Int. J. Med. Sci. 2009 6 114 Short Communication International Journal of Medical Sciences 2009 6 3 114-115 Ivyspring International Publisher. All rights reserved Ocular Manifestations of West Nile Virus Infection Salim Ben Yahia Moncef Khairallah Department of Ophthalmology Fattouma Bourguiba University Hospital Monastir Tunisia Published West Nile Virus WNV first isolated in 1937 in the West Nile district of Uganda is a single-stranded RNA flavivirus. It is a member of the Japanese encephalitis serogroup. WNV infection is a zoonotic disease transmitted by a mosquito vector type Culex with wild birds serving as its reservoir. The disease is endemic in Europe Australia Asia Africa and North and Central America since its appearance in New York in Most human infections are subclinical 80 or manifest as febrile illness 20 . Severe neurologic disease meningoencephalitis frequently associated with advanced age and diabetes was initially reported to occur in less than 1 of patients. However over time WNV infection has increased in severity. The diagnosis is confirmed by detection of IgM antibody in serum or cerebrospinal A typical multifocal chorioretinitis frequently asymptomatic is the most common ocular manifestation of WNV infection 80 .2 Active chorioretinal lesions appear as circular deep creamy lesions on ophthalmoscopy with early hyopofluorescence and late staining on fluorescein angiography FA . Inactive chorioretinal lesions typically are partially atrophic and partially pigmented with a targetlike appearance central hypofluorescence and peripheral hyperfluorescence on FA Figure 1 . Chorioretinal lesions vary in number and size involving the midperiphery with or without involvement of the posterior pole. Linear clustering of chorioretinal lesions following the course of retinal nerve fibers is a prominent feature 80 . Indocyanine green angiography shows more lesions in the form of hy-pofluorescent spots than those appreciated .