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Báo cáo y học: "Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report'

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema: a case report. | Journal of Medical Case Reports BioMed Central Open Access Case report Minocycline-induced hypersensitivity syndrome presenting with meningitis and brain edema a case report Nicolas Lefebvre 1 Emmanuel Forestier1 David Farhi2 Mohseni Zadeh Mahsa1 Véronique Remy1 Olivier Lesens1 Daniel Christmann1 and Yves Hansmann1 Address Department of Infectious Diseases and Tropical medicine Teaching Hospital Strasbourg France and 2Department of Dermatology Tarnier Hospital Paris France Email Nicolas Lefebvre - n.lefebvre@yahoo.fr Emmanuel Forestier-emmanuel.forestier@chru-strasbourg.fr David Farhi - farhidavid@yahoo.fr Mohseni Zadeh Mahsa - mahsa.mohseni.zadeh@chru-strasbourg.fr Véronique Remy - veronique.remy@ch-cahors.fr Olivier Lesens - olesens@chu-clermontferrand.fr Daniel Christmann - daniel.christmann@chru-strasbourg.fr Yves Hansmann - yves.hansmann@chru-strasbourg.fr Corresponding author Published 18 May 2007 Received 12 December 2006 Journal of Medical Case Reports 2007 1 22 doi 10.1186 1752-1947-1-22 Accepted 18 May 2007 This article is available from http www.jmedicalcasereports.cOm content 1 1 22 2007 Lefebvre et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Background Hypersentivity Syndrome HS may be a life-threatening condition. It frequently presents with fever rash eosinophilia and systemic manifestations. Mortality can be as high as 10 and is primarily due to hepatic failure. We describe what we believe to be the first case of minocycline-induced HS with accompanying lymphocytic meningitis and cerebral edema reported in the literature. Case presentation A 31-year-old HIV-positive female of African origin presented with acute fever lymphocytic meningitis brain edema rash eosinophilia and cytolytic hepatitis. She had