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Báo cáo y học: "Dexamethasone inhibits IL-9 production by human T cells"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Dexamethasone inhibits IL-9 production by human T cells. | Journal of Inflammation BioMed Central Research Dexamethasone inhibits IL-9 production by human T cells Lauren E Holz11 2 Kristoffer P Jakobsen11 Jacques Van Snick3 Francoise Cormont3 and William A Sewell 1 2 4 Open Access Address 1Garvan Institute of Medical Research 384 Victoria St Darlinghurst NSW 2010 Australia 2Centre for Immunology St. Vincent s Hospital University of NSW NSW 2052 Australia 3Ludwig Institute of Cancer Research Brussels Branch and the Experimental Medicine Unit Universite de Louvain B-1200 Brussels Belgium and 4St Vincent s Clinical School University of NSW NSW 2052 Australia Email Lauren E Holz - l.holz@centenary.usyd.edu.au Kristoffer P Jakobsen - porsj@hotmail.com Jacques Van Snick - vansnick@mail.icp.ucl.ac.be Francoise Cormont - francoise.cormont@gskbio.com William A Sewell - w.sewell@garvan.org.au Corresponding author tEqual contributors Published 20 April 2005 Journal of Inflammation 2005 2 3 doi 10.1 186 1476-9255-2-3 Received 03 December 2004 Accepted 20 April 2005 This article is available from http www.journal-inflammation.cOm content 2 1 3 2005 Holz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Interleukin 9 IL-9 is produced by activated CD4 T cells. Its effects include stimulation of mucus production enhanced mast cell proliferation enhanced eosinophil function and IgE production. These effects are consistent with a role in allergic diseases. Glucocorticoids have potent anti-inflammatory effects including suppression of cytokine synthesis and are widely used in the treatment of allergic conditions. Methods We examined the effect of the glucocorticoid dexamethasone Dex on IL-9 mRNA expression and protein secretion with real-time RT-PCR and ELISA. Peripheral blood