tailieunhanh - Báo cáo y học: "Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel, liposomal delivery of dexamethasone phosphate: long-term suppression of arthritis facilitates interval treatment. | Available online http content 11 6 R190 Research article Separating therapeutic efficacy from glucocorticoid side-effects in rodent arthritis using novel liposomal delivery of dexamethasone phosphate long-term suppression of arthritis facilitates interval treatment Una Rauchhaus1 Franz Werner Schwaiger2 and Steffen Panzner1 1Novosom AG Weinbergweg 22 D-06120 Halle Saale Germany 2Aurigon Life Science GmbH Bahnhofstrasse 9-15 D-82327 Tutzing Germany Corresponding author Steffen Panzner Received 26 Mar 2009 Revisions requested 21 Apr 2009 Revisions received 24 Nov 2009 Accepted 15 Dec 2009 Published 15 Dec 2009 Arthritis Research Therapy 2009 11 R190 doi 86 ar2889 This article is online at http content 11 6 R190 2009 Rauchhaus et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Glucocorticoids have extensively been used in the treatment of rheumatoid arthritis and other inflammatory diseases. However their side-effects remain the major limitation in clinical use and an improved therapeutic index is needed. Methods Therapeutic efficacy and persistence of free and liposomal dexamethasone phosphate DXM-P were determined in mouse collagen-induced arthritis. For regimens with equal therapeutic benefit the side-effect profiles were analysed over time with respect to collagen breakdown suppression of the hypothalamus-pituitary-adrenal HPA axis changes in blood glucose levels and the haematological profile. In addition the presence of drug was monitored in plasma. Results Liposomal DXM-P but not free drug resulted in a persistent anti-inflammatory effect. Comparable clinical benefit was achieved with a single .