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Báo cáo y học: " The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:: " The effect of IL-13 and IL-13R130Q, a naturally occurring IL-13 polymorphism, on the gene expression of human airway smooth muscle cells. | Respiratory Research BioMed Central Research Open Access The effect of IL-13 and IL-I3RI30Q a naturally occurring IL-13 polymorphism on the gene expression of human airway smooth muscle cells Farhat Syed 1 Reynold A Panettieri Jr2 Omar Tliba2 Chris Huang1 Katherine Li1 Michelle Bracht1 Bernard Amegadzie1 Don Griswold1 Li Li1 and Yassine Amrani 2 Address 1Centocor Inc. 200 Great Valley Parkway Malvern PA 19355. USA and 2Pulmonary Allergy and Critical Care Division Department of Medicine University of Pennsylvania Room 848 BRBII III 421 Curie Boulevard Philadelphia PA 19104. USA Email Farhat Syed - fsyed@cntus.jnj.com Reynold A Panettieri - rap@mail.med.upenn.edu Omar Tliba - omartlib@mail.med.upenn.edu Chris Huang - CHuang4@cntus.jnj.com Katherine Li - Kli@cntus.jnj.com Michelle Bracht - Mbracht@cntus.jnj.com Bernard Amegadzie - BAmegadz@cntus.jnj.com Don Griswold - DGriswol@cntus.jnj.com Li Li - Lli14@cntus.jnj.com Yassine Amrani - amrani@mail.med.upenn.edu Corresponding authors Published 20 January 2005 Received 08 December 2004 Respiratory Research 2005 6 9 doi 10.1186 1465-9921-6-9 Accepted 20 January 2005 This article is available from http respiratory-research.cOm content 6 1 9 2005 Syed et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Growing evidence shows that interleukin 13 IL-13 may play an essential role in the development of airway inflammation and bronchial hyper-responsiveness BHR two defining features of asthma. Although the underlying mechanisms remain unknown a number of reports have shown that IL-13 may exert its deleterious effects in asthma by directly acting on airway resident cells including epithelial cells and airway smooth muscle cells. In this report we hypothesize that .