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Báo cáo y học: "Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: "Modulation of epithelial sodium channel (ENaC) expression in mouse lung infected with Pseudomonas aeruginosa. | Respiratory Research BioMed Central Research Open Access Modulation of epithelial sodium channel ENaC expression in mouse lung infected with Pseudomonas aeruginosa André I Dagenais - 1 Diane Gosselin-2 Claudine Guilbault3 Danuta Radzioch3 and Yves Berthiaume1 Address 1Centre de recherche Centre hospitalier de l Université de Montréal Hôtel-Dieu Département de médecine Université de Montréal Montreal Quebec Canada 2Present address Fonds de solidarité FTQ Montreal Quebec Canada and 3Departments of Experimental Medicine and Human Genetics McGill University Montreal Quebec Canada Email André Dagenais - andre.dagenais.chum@ssss.gouv.qc.ca Diane Gosselin - dgosselin@fondsftq.com Claudine Guilbault - claudine.guilbault@mail.mcgill.ca Danuta Radzioch - danuta.radzioch@muhc.mcgill.ca Yves Berthiaume - yves.berthiaume@umontreal.ca Corresponding author fEqual contributors Published 06 January 2005 Received 21 November 2003 Respiratory Research 2005 6 2 doi l0.ll86 l465-992l-6-2 Accepted 06 January 2005 This article is available from http respiratory-research.cOm content 6 l 2 2005 Dagenais et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The intratracheal instillation of Pseudomonas aeruginosa entrapped in agar beads in the mouse lung leads to chronic lung infection in susceptible mouse strains. As the infection generates a strong inflammatory response with some lung edema we tested if it could modulate the expression of genes involved in lung liquid clearance such as the a p and Y subunits of the epithelial sodium channel ENaC and the catalytic subunit of Na -K -ATPase. Methods Pseudomonas aeruginosa entrapped in agar beads were instilled in the lung of resistant BalB c and susceptible DBA 2 C57BL 6 and A J .