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Báo cáo y học: "Importance of lysosomal cysteine proteases in lung disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"Importance of lysosomal cysteine proteases in lung disease. | http respiratory-research.eom content 1 3 170 Review Importance of lysosomal cysteine proteases in lung disease Paul J Wolters and Harold A Chapman Department of Medicine and Cardiovascular Research Institute University of California San Francisco California USA Received 10 October 2000 Revisions requested 7 November 2000 Revisions received 10 November 2000 Accepted 10 November 2000 Published 20 November 2000 Respir Res 2000 1 170-177 Current Science Ltd Print ISSN 1465-9921 Online ISSN 1465-993X Abstract The human lysosomal cysteine proteases are a family of 11 proteases whose members include cathepsins B C H L and S. The biology of these proteases was largely ignored for decades because of their lysosomal location and the belief that their function was limited to the terminal degradation of proteins. In the past 10 years this view has changed as these proteases have been found to have specific functions within cells. This review highlights some of these functions specifically their roles in matrix remodeling and in regulating the immune response and their relationship to lung diseases. Keywords asthma cathepsin emphysema extracellular matrix invariant chain Introduction Members of the papain family of cysteine proteases are found predominantly within the endosomal and lysosomal compartment of cells. It was initially believed that they were housekeeping genes and that they functioned exclusively as the cell s garbage disposals terminally degrading unwanted abnormal or endocytosed proteins. Recently this view has evolved as members of the family have been found to have distinctive patterns of expression Table 1 have regulated expression have important roles in specific biologic processes 1 2 and have been linked to inherited genetic diseases 3-5 . The first members of the papain family of cysteine proteases included cathepsins B C H L and S. During the past ten years six new members have been added giving 11 Table 1 . Cathepsins B C F H O and Z are constitutively .