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Báo cáo y học: "CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:"CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation, EGF receptor transactivation and ERK1/2 phosphorylation. | Respiratory Research BioMed Central Research Open Access CysLT1 receptor-induced human airway smooth muscle cells proliferation requires ROS generation EGF receptor transactivation and ERK1 2 phosphorylation Saula Ravasi1 Simona Citro1 Barbara Viviani2 Valérie Capra1 and G Enrico Rovati 1 Address laboratory of Molecular Pharmacology Section of Eicosanoid Pharmacology Department of Pharmacological Sciences University of Milan Via Balzaretti 9 20133 Milan Italy and 2Laboratory of Toxicology Department of Pharmacological Sciences University of Milan Via Balzaretti 9 20133 Milan Italy Email Saula Ravasi - Saula.Ravasi@unimi.it Simona Citro - Simona.Citro@unimi.it Barbara Viviani - Barbara.Viviani@unimi.it Valérie Capra - Valerie.Capra@unimi.it G Enrico Rovati - GEnrico.Rovati@unimi.it Corresponding author Published 22 March 2006 Received 13 January 2006 Respiratory Research 2006 7 42 doi 10.1186 1465-9921 -7-42 Accepted 22 March 2006 This article is available from http respiratory-research.cOm content 7 1 42 2006 Ravasi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cysteine-containing leukotrienes cysteinyl-LTs are pivotal inflammatory mediators that play important roles in the pathophysiology of asthma allergic rhinitis and other inflammatory conditions. In particular cysteinyl-LTs exert a variety of effects with relevance to the aetiology of asthma such as smooth muscle contraction eosinophil recruitment increased microvascular permeability enhanced mucus secretion and decreased mucus transport and finally airway smooth muscle cells ASMC proliferation. We used human ASMC HASMC to identify the signal transduction pathway s of the leukotriene D4 LTD4 -induced DNA synthesis. Methods Proliferation of .