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Báo cáo y học: "Antinuclear antibodies in healthy people: the tip of autoimmunity’s iceberg? David S Pisetsky1,2"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Antinuclear antibodies in healthy people: the tip of autoimmunity’s iceberg? David S Pisetsky1,2. | Pisetsky Arthritis Research Therapy 2011 13 109 http arthritis-research.eom content 13 2 109 EDITORIAL Antinuclear antibodies in healthy people the tip of autoimmunity s iceberg David S Pisetsky1 2 See related research by Li etal. http arthritis-research.eom content 13 2 R38 Abstract Antinuclear antibodies ANAs are venerable biomarkers for assessing the diagnosis and prognosis of patients with autoimmunity. While closely associated with diseases such as systemic lupus erythematosus ANA expression occurs commonly in healthy people. The basis for this expression is unknown although it may reflect features of the assays for antibody detection or intrinsic immunological disturbances in otherwise normal individuals. Like autoimmunity itself ANA expression is more common among women than men pointing to an important determinant of these responses. Future research will clarify the mechanisms of ANA expression and the utility of current assays as antecedent and screening biomarkers. Throughout medicine investigators are in hot pursuit of biomarkers. These biomarkers many of which involve multiplex assays or omic technologies come in a variety of flavors antecedent disease risk screening subclinical disease diagnostic staging and prognostic. Among their uses biomarkers can help elucidate genetic predisposition to disease and identify triggering events practically such markers can allow early diagnosis and treatment and the development of strategies for risk reduction. Although biomarker technology can be unbelievably complex the principles are straightforward and provide hope for improved patient outcomes. As the study by Li and colleagues in Arthritis Research and Therapy indicates 1 the use of antinuclear antibodies ANAs one of the most venerable tests in immunology as antecedent or screening biomarkers while potentially very informative faces major challenges. Correspondence piset001@mc.duke.edu 1Medical Research Service Durham Veterans Administration Medical Center 508